Structure/Function Analysis
of the Amino-Terminal Domain
of the Androgen Receptor

Acta Biomedica Lovaniensia, No. 308

By Leen Callewaert
April 2004
Leuven University Press
ISBN: 90-5867-367-7
135 pages, Illustrated, 6 " x 9 "
$65.00 Paper Original


This is a Ph.D. dissertation. The amino-terminal domain (NTD) of the androgen receptor (AR) is indispensable for AR transactivation and contains a strong activation function 1. Its activity is affected by coregulators that influence a number of functional properties of AR.

The NTD of the AR is 529 aa long and is a complex domain with several functions, namely p160 recruitment, interaction with the LBD, and it contains two transactivation functions Tau-1 And Tau-5. The aim of this study was to obtain a more detailed structure-function analysis of the NTD of the AR.

Contents include: Introduction, N/C Interaction in AR-mediated Transactivation, Polyglutamine Stretch, SUMOylation of the AR, Activation Function of the hAR, Discussion, Summary and conclusions, Future Prospects.

Biochemistry

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