Protein-Bound Solute p-Cresol
Generation, Elimination & Clinical Implications
in Patients with Chronic Kidney Disease

By Bert Bammens
Acta Biomedica Lovaniensia, No. 347
November 2005
Leuven University Press
ISBN: 9058674827
249 pages, 6” x 9 ½”
$125.00 Paper Original

This is a Ph.D. thesis. The exact pathogenic mechanisms underlying the myriad changes occurring in case of renal failure are not completely understood today. Nevertheless, it is generally accepted that the progressive retention of compounds which under normal conditions are excreted by the healthy kidneys plays a central role.

By convention, these so-called uremic retention solutes are classified according to their molecular mass. When they are listed according to their lipophilicity/hydrophilicity, another characteristic potentially influencing their removal pattern during dialysis, a distinct group of solutes appears at the horizon: protein-bound molecules.


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