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Progress in Gene Therapy
Basic & Clinical Frontiers
Edited by R. Bertolotti, S.H. Parvez, T. Nagatsu
558 Pages, Illustrated
Preface; Gene therapy: transient or long-term minigene expression and gene repair/inactivation; Higher-titer retroviral pseudotype vectors for specific targeting of human CD4-positive cells;Lentiviral vectors for gene therapy; Helper dependent adenoviral vectors -- improved safety and expression; Adeno-associated virus: basic biology and vector applications; Herpes simplex virus vectors for gene therapy; Liver-selective nucleic acid delivery using the asialoglycoprotein receptor; Receptor-mediated gene transfer based on plasmid DNA complexes; Gene delivery by guanidinium-cholesterol cationic lipids: a 1999 update;Progress of fusigenic viral-liposomes; Gene therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency;Transgenic rescue of tyrosine hydroxylase-deficient mice: application for generating animal models with cateholamine dysfunction; Adeno-associated virus (AAV) vectors and gene therapy of Parkinson's disease; Bystander effect in suicide gene therapy of cancers; Vaccination strategies for advanced melanoma; Apoptin induces tumor-specific apoptosis: potentials for a novel anti-tumor therapy; Human DNA immunization with regulatory HIV-1 genes; Alphavirus vectors: from RNA replicons to suicidal DNA vaccines; Anti-HIV ribozymes in the inhibition of HIV and AIDS; Alteration of pre-mRNA splicing patterns by modified small nuclear RNAs; Single-base conversion of mammalian genes by an RNA-DNA oligonucleotide; Gene therapy: dsDNA-cored presynaptic filaments as vectors for gene repair and targeted integration of transgenes.