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Positional Cloning of X-Linked Mental Retardation Genes

By Jun Lin
December 2001
Leuven University Press
ISBN: 90-5867-168-2
105 pages, illustrated
$51.50 paper original

Contents: Introduction. The Human X-chromosome. Mental Retardation. X-linked Mental Retardation. Positional Cloning of XLMR genes. Rationale and aims. Materials and methods. General Molecular Cloning Techniques. Linkage Analysis. Fluorescence in situ Hybridization. Genomic Clone Resources. STSs and STS. Content Mapping. Cloning the Breakpoints. RT-PCR and RACE. Genomic Structure Determination. Mutation Screening. Identification of the Mouse Orthologs. Expression Studies. Results and Discussion. New Member of the IL1 Receptor Family Highly Expressed in Hippocampus and Involved in X-linked Mental Retardation. IL1RAPL2, A Novel Member of IL1 Receptor Family, is an XLMR Candidate Gene. NXF5, A Novel Member of the Nuclear RNA Export Family Involved in Mental Retardation. Summary and Prospects. Samenvatting. References. Bibliography.

Acta Biomedica Lovaniensia, No. 244