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Pathophysiology of Calcification of Bioprosthetic Heart Valves
An Experimental Investigation

By Shigeyuki Ozaki
October 2001
Leuven University Press
ISBN: 9058671429
116 pages, illustrated
$84.50 paper original


Introduction. Clinical Results for stente bioprosthetic heart valves. Determinants of bioprosthetic heart valve calcification. Prevention of calcification by design changes. Existing animal models for the study of prosthetic valve calcification. Goals of the present study. Methodology. Rat subcutaneous model. Blood contact model. Pulsatile model. Results and discussion. A new model to test calcification characteristics of bioprosthetic heart valves. Calcification characteristics in porcine stentless valves. Influence of stenting on the degeneration and calcification of glutaraldehude-pretreated porcine aortic valve bioprostheses. Influence of blood contact on the calcification of glutaraldehyde-pretreated porcine aortic valves. Testing an alternative corss-linker to gluturaldehyde

Doctoral thesis.

Cardiology
Acta Biomedica Lovaniensia, No. 238