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The Pathogenesis of Alzheimer's Disease
A Study in Transgenic Mice

By Jo Van Dorpe
October 2001
Leuven University Press
ISBN: 9058671267
153 pages, illustrated
$84.50 paper original


  1. General introduction

    1. Alzheimer's disease
    2. Cerebral amyloid angiopathy
    3. Amyloid precursor protein
    4. Tau protein
  2. Rationale, Aims and Approaches
  3. Materials and methods
  4. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons
  5. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
  6. Tau pathology in single transgenic APP/LD, double transgenic APP/LDXTau40, and tripple transgenic APP/LDXTau40XPS1/Mut Mice
  7. Summary/samenvatting
  8. Publications/References

Doctoral thesis.

Neurology; Medicine
Acta Biomedica Lovaniensia, No. 230