Characterization & Therapeutic Assessment
of Rodent Stroke with Magnetic Resonance
Imaging at a 1.5 Tesla Clinical Scanner

Acta Biomedical Lovaniensia, No. 380

By Feng Chen
May 2007
Leuven University Press
Distributed By
ISBN: 9789058675866                                                             
152 pages, Illustrated, 6 1/4 x 9 1/2"
$97.50 Paper Original

Chapter 1: Introduction
1.1. Ischemic stroke: pathogenesis and cascade
1.2. Ischemic stroke studies in animals
1.3. Treatment of stroke in rats
1.4. MRI evaluation of cerebral ischemia in rats
1.5. Purpose of the study
Chapter 2: Feasibility study of using clinical MRI system in a rat stroke model
2.1. Visualization of stroke with clinical MR imagers in rats: a feasibility study
2.2. Dynamic susceptibility contrast-enhanced perfusion MR imaging at 1,5 T predicts final infarct size in a rat stroke model
2.3. Rat cerebral ischemia induced with photochemical occlusion of proximal middle cerebral artery: a stroke model for MR imaging research
Chapter 3: MRI characterization of the PIT stroke model
3.1. Delayed perfusion phenomenon in a rat stroke model at 1,5 T MR: an imaging sign parallel to spontaneous reperfusion and ischemic penumbra?
3.2. Perfusion-diffusion mismatch in a rat stroke model: dependence on early or instantly acquired perfusion weighted MRI
3.3. Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MRI and histopathology
Chapter 4: The role of MRI in the treatment of stroke in rats
4.1. Microplasmin reduces ischemic brain damage and improves neurological function in a rat stroke model monitored with MRI
4.2. Multiparametric MR imaging for comparison of therapeutic effects between microplasmin and tissue plasminogen activator on rodent stroke
Chapter 5: General discussion and perspectives
5.1. Advantages of 1,5 T MR imaging
5.2. The PIT model
5.3. Therapeutic effects monitored with MRI
5.4. Summary


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