Cellular Mechanisms of Mammalian
Heparanase Uptake & Activation
Acta Biomedica Lovaniensia, No. 402

By Veronique Vreys    
November 2007
Leuven University Press                                                        
Distributed by
ISBN: 9789058676238                                                     
148 pages, Illustrated, 6 1/8 x 9 1/2"
$99.50 Paper Original

                 

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Contents Include:

Summary
Introduction
-Heparan sulfate proteoglycans
-Heparanase
Objectives and Outline of the Thesis
Results
-4.1 Manuscript 1: Cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose-6-phosphate receptors and heparan sulfate proteoglycans
-4.2 Manuscript 2: Low density lipoprotein receptor-related proteins and heparan sulfate proteoglycans form a high affinity dual receptor-complex involved in the (re)capture of both the precursor and mature form of mammalian heparanase
-4.3 Manuscript 3: Human heparanase-2 compared with human heparanase-1: heparan sulfate-degrading activity, proteolytic processing and trafficking
-4.4 Manuscript 4: Llama heavy-chain antibodies specific for human heparanase-1: effects on heparanase-1 uptake and activation by cells
General Discussion and Future Prospects
Bibliography                 

Medical Science


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