Long-Term Clinical Pharmacokinetic
Study of Tacrolimus & Mycophenolic
Acid & Metabolites in De Novo
Renal Allograft Recipients

By Dirk Kuypers
November 2003
Leuven University Press
ISBN: 90-5867-324-3
216 pages, Illustrated, 6 " x 9 "
$67.50 Paper Original

Contents of this Ph.D. dissertation include: Introduction, Time-dependent clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and glucocorticosteroids: a prospective study in one hundred de novo renal transplant recipients, Long-term changes of mycophenolic acid (MPA) pharmacokinetics in combination with tacrolimus and glucocorticosteroids are dose-dependent and not reflected by trough plasma concentration: a prospective study in one hundred de novo renal allograft recipients, Long-term clinical efficacy and toxicity profiles of tacrolimus and mycophenolic acid in relation to drug exposure: a twelve-month prospective pharmacokinetic study in de novo renal allograft recipients, Twelve month evaluation of the clinical pharmacokinetics of total and free mycophenolic acid and its glucuronide metabolites in renal allograft recipients on low dose tacrolimus in combination with mycophenolate mofetil, Long-term pharmacokinetic study of the novel combination of tacrolimus and sirolimus in de novo renal allograft recipients.

Acta Biomedica Lovaniensia No. 294

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